EXPERIMENTAL APPROACHES Mechanism of Adrenalin Pulmonary Edema

The dynamics of palmonary edema c a d by adrenalin was studied by left and right heart catheterizations in rabbits. It was 84~ertabed that the injection is followed by marked systolic hypertension, increase of the left venMcalar dp/dt, and, at the same time, an elevation of left venMclllar dbtolic preswres to levels of 60-80 mm Hg. These changes are similar to those previously observed in the dog for other typea of palmonary edema. The actions of narcotics and autonomic Mockers in preventing pulmonary edema were studied. The effect of morphine was moderate; that of cbloralose, minimal; that of pentobarbital, again moderate. Whik p h e n o x y b e d e completely prevented pulmonary edema and insured total wupival, Mmethaphan insured total suwival but &id not prevent pnlmonary edema. These resnlts suggest that death can be caused by eitber pulmonary edema or other mechanisms